Conformational Epitope Prediction Server

Developed@Bioinformatics Centre, University of Pune, INDIA

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Evaluation of CEP algorithm using Ag-Ab complexes from PDB

IR: Interacting Residues
BR: Buried Residues 
BS: Binding Site
CE: Conformational Epitope
SE: Sequential Epitope
SE best represents the BS

No. PDB_ID Antigen IR BR BS Predicted CE
Prediction
status(>60%)
Residues correctly predicted(%) Residues missed
1 1FDL Lysozyme

14

4

18

13(72) 5

Yes

2 1BQL Lysozyme

13

8

21

18(85)

3

Yes

3 1DQJ Lysozyme

19

6

25

15(60)

10

Yes

4 1FBI Lysozyme

14

12

26

20(77)

6

Yes

5 1JHL Lysozyme

10

9

19

15(78)

4

Yes

6 1MLC Lysozyme

16

4

20

17(85)

3

Yes

7 3HFM Lysozyme

15

8

23

15(65)

8

Yes

8 1A14

Neuraminidase

16

4

20

13 (65)

7

Yes

9 1NCA

Neuraminidase

20

11

31

09(29)

22

No

10 2JEL

Histidine-containing protein

15

7

22

19(86)

3

Yes

11 1WEJ Cytochrome c

12

3

15

06(40)

9

No

12

1IGC

Protein G

13

3

16

16(100)

0

Yes

13

1FSK

Major Pollen Allergen Bet V1-A

17

6

23

15(65)

8

Yes

14 1EGJ

Cytokine receptor common b chain

10

5

15

15(100)

0

Yes

15

1E6J

Capsid Protein (P24)

11

4

15

15(100)

0

Yes

16

1BGX

Taq DNA Polymerase

46

10

57

26(45)

31

No

17 1JRH

Interferon-g receptor a-chain

15

5

20

15(75)

5

Yes

18 1OAK

Von Willebrand Factor

12

4

16

13(81)

3

Yes

19

1OSP

Outer surface protein A (OSPA)

19

4

23

9(39)

14

No

20

1ADQ

Igg4 Rea (Fc)

16

7

23

14(60)

9

Yes

21 1NSN Nuclease ribonucleate

17

13

30

10(33)

20

No

                 
22 1C08 Hen lysozyme     30 21(70) 9 Yes
23 1JTT Lysozyme     9 7(77) 2 Yes
24 NCB Neuraminidase     30 9(30) 21 No
25 1BJ1 Vascular endothelial growth factor     18 18(100) 0 Yes
26 1QFU Hemagglutinin     28 15(54) 13 No
27 1FNS Von willebrand factor     17 13(76) 4 Yes
28 1G9M T-cell surface glycoprotein     13 6(46) 7 No
29 1H0D Human angiogenin     21 16(76) 5 Yes
30 1HEZ Protein 1     26 25(96) 1 Yes
31 1IQD Human factor viii     22 10(45) 12 No
32 1QFW Gonadotrophin beta subunit     10 8(80) 2 Yes
33 1QLE Cytochrome c oxidase      25 5(20) 20 No
34 1S5H potassium channel 15 14(93) 1 Yes
35 1UWX outer membrane protein     18 18(100) 0 Yes
36 1WEJ horse cytochrome c     22 8(36) 14 No
37 2AP2 p-glycoprotein     19 18(95) 1 Yes
38 2BOB Potassium channel kcsa fragment     14 14(100) 0 Yes
39 3CK0 Human angiotensin ii     5 5(100) 0 Yes
40 1ACY HIV-1     8 6(75) 2 Yes
41 1AHW Extracellular domain of Tissue factor     20 17(85) 3 Yes
42 1CZ8 Vascular endothelial growth factor     32 11(34) 21 No
43 1DEE staphylococcus aureus domain     13 11(84) 2 Yes
44 1EO8 Influenza virus hemagglutinin     23 11(48) 12 No
45 1EZV Yeast cytochrome BC1     23 17(74) 6 Yes
46 1G6V bovine carbonic anhydrase     21 15(71) 6 Yes
47 1GC1 HIV-1 GP120     11 8(72) 3 Yes
48 1JPS tissue factor     35 26(74) 9 Yes
49 1K4C Potassium Channel KcsA     20 16(80) 4 Yes
50 1N5Y HIV-1 Reverse Transcriptase     17 16(94) 1 Yes
51 1N8Z human HER2     22 19(86) 3 Yes
52 1ORS KvAP potassium channel voltage sensor     13 13(100) 0 Yes

 

Last updated: Urmila Kulkarni-Kale, August 21, 2006